rab protein


J Biol Chem. The specific binding of the effector to the Rab protein allows the Rab protein to be effective, and conversely, the conformation shift of the Rab protein to the inactive state leads to effector dissociation from the Rab protein.[3]. The Rab family of proteins is a member of the Ras superfamily of small G proteins. J Biol Chem. Nature Chemistry. Herm-Gotz A, Agop-Nersesian C, Munter S, Grimley JS, Wandless TJ, Frischknecht F, et al. 2003) like human Rab8 and Rab23 (Casey and Seabra 1996) and ARA6 from Arabidopsis thaliana (Ueda et al. They are localized to the cytoplasmic face of organelles and vesicles involved in the biosynthetic/secretory and endocytic pathways in eukaryotic cells. A GDP dissociation inhibitor (GDI) binds the prenyl groups of the inactive, GDP-bound form of Rab, inhibits the exchange of GDP for GTP (which would reactivate the Rab) and delivers Rab to its original membrane. Four distinct pathways of hemoglobin uptake in the malaria parasite. Hemoglobin degradation.

[2] Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways? Agop-Nersesian C, Egarter S, Langsley G, Foth BJ, Ferguson DJ, Meissner M. Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B. Come la proteina Ras, infatti, anche le proteine Rab si legano al GTP e lo idrolizzano: queste proteine, con attività GTPasica, sono anche considerate “switch protein” o “proteine interruttore” in quanto l’attività intrinseca di esse causa l’idrolisi del GTP a GDP e Pi e, contemporaneamente, il passaggio dalla forma attiva a quella inattiva della proteina stessa. 2000). Proc Natl Acad Sci U S A. By characterizing the different Plasmodium Rabs, one will gain insight not only into how the parasite regulates its vesicular traffic, but as Rabs are specific for different subcellular compartments, it also has the potential to identify various parasite subcellular organelles known only by their descriptive names: rhoptries, micronemes, and dense granules, as early endosomes, late endosomes, recycling endosomes, etc. However, another prenyl protein transferase, geranylgeranyltransferase II, catalyzes the covalent addition of the more hydrophobic C20 geranylgeranyl isoprenoid to carboxyl-terminal cysteine residues found in CC, CXC, or CXXX motifs (C, cysteine; X, any amino acid).

Phagosomal acidification and recruitment of cathepsin D are regulated by Rab GTPases. Effector proteins have one of four different functions.

Autophagy. Vesicular traffic is very dynamic and permits the cargo contained within the vesicle to traffic from donor to acceptor membranes. [6], Mutations in the GDI1 gene have been shown to lead to X-linked nonspecific intellectual disability. Support for this notion comes for the ability in vitro of PfRab11A (PF3D7_1320600) to pull down myosin light chain 1, MTIP/MLC1 (PF3D7_1246400) (Agop-Nersesian et al. In this context it is noteworthy that both PfRab5A and PfRab7 can bind P. falciparum cAMP-dependent protein kinase A (PKA), and in addition, PfRab5B binds casein kinase 1 (PfCK1, PF3D7_1136500.1) (Rached et al. By continuing you agree to the use of cookies. The phosphoproteomes of, Ueda T, Yamaguchi M, Uchimiya H, Nakano A. Ara6, a plant-unique novel type Rab GTPase, functions in the endocytic pathway of, Vaid A, Ranjan R, Smythe WA, Hoppe HC, Sharma P. PfPI3K, a phosphatidylinositol-3 kinase from. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Chattopadhyay D, Smith CD, Barchue J, Langsley G. Plasmodium falciparum rab6 GTPase: expression, purification, crystallization and preliminary crystallographic studies.

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